In general, the FDA regulations for dietary supplements are different from those for prescription or over-the-counter drugs. Unlike drugs, which must be approved by the FDA before they can be marketed, dietary supplements do not require premarket review or approval by the FDA. While the supplement company is responsible for having evidence that their products are safe and the label claims are truthful and not misleading, they do not have to provide that evidence to the FDA before the product is marketed.
There's not much doubt about this one: Women need more iron than men, because they lose iron with each menstrual period. After menopause, of course, the gap closes. The RDA of iron for premenopausal women is 18 mg a day, for men 8 mg. Men should avoid excess iron. In the presence of an abnormal gene, it can lead to harmful deposits in various organs (hemochromatosis). Since red meat is the richest dietary source of iron, it's just as well that men don't need to wolf down lots of saturated fat to get a lot of iron.
Women, as we age, are also more susceptible to the breakdown of our bones, which may result in osteoporosis over time. Genetically, women have a particularly high risk of osteoporosis compared to men, so it’s recommended that women monitor their calcium intake to be sure they’re getting enough. Weight training is another great way (and my favorite!) to build bone density, which is another great reason you should hit the weights!
For instance, foods rich in vitamin E and beta-carotene are healthy and can help reduce cancer risk. However, the U.S. Preventive Services Task Force (USPSTF) and the American Academy of Family Physicians (AAFP) recommend against taking vitamin E or beta-carotene for the prevention of cardiovascular disease. People who smoke or are at risk for lung cancer also should avoid beta-carotene. It can increase their risk of lung cancer.
Another spin on the 80/20 rule, says Dr. Lipman: stopping eating when you're 80% full. That means slowing down and checking in periodically throughout the meal about what your body is saying. Does the food no longer taste great? Are you getting that "I don't really need any more feeling"? Thinking 80/20 as you eat can help slow you down and be more mindful. Being in tune with your body prevents overeating, he says.

Dietary supplements are complex products. The FDA has established good manufacturing practices (GMPs) for dietary supplements to help ensure their identity, purity, strength, and composition. These GMPs are designed to prevent the inclusion of the wrong ingredient, the addition of too much or too little of an ingredient, the possibility of contamination, and the improper packaging and labeling of a product. The FDA periodically inspects facilities that manufacture dietary supplements.
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